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. Author manuscript; available in PMC: 2012 Oct 13.
Published in final edited form as: J Med Chem. 2011 Sep 13;54(19):6492–6500. doi: 10.1021/jm200114f

Figure 1. Peptide optimization overview.

Figure 1

An overview of the peptide optimization framework. The procedure is based on data that associates peptides with an activity score (e.g., endothelial cell proliferation inhibition activity). The peptides are converted into unique sparse vectors. We use convex optimization to select features that differentiate high activity peptides from low performing peptides. The selected features can be used to help understand the structure activity relationships of the peptides. New peptides can be synthesized based on the SAR information. A feedback loop can be created by adding new experimentally tested peptides to the database.