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. Author manuscript; available in PMC: 2012 Oct 13.
Published in final edited form as: J Med Chem. 2011 Sep 13;54(19):6492–6500. doi: 10.1021/jm200114f

Figure 5. Endothelial tube formation assay.

Figure 5

Endothelial cell tube formation assays are useful indicators of angiogenesis potential. (A) Tube formation for the positive control (vehicle control). Entothelial cell tube formation without an added compound. HUVECs form robust tube structures (B) Endothelial cell tube formation with the addition of 100μM of 8. The figure shows only partial inhibition of tube structures. (C) 100μM of 27 completely inhibits the formation of tube structures. (D) 100μM of 35 completely inhibits the formation of tube structures.