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Model of PDGF-induced SSH1L activation in VSMC. PDGF stimulates Nox 1 to produce ROS. The Nox1-produced ROS then oxidizes 14-3-3, releasing SSH1L phosphatase which now can dephoshorylate other SSH1L molecules, facilitating the disruption of the inhibitory complex with 14-3-3 and thus increasing SSH1L phosphatase activity.
