Table 4. Distribution of mutation sites predicted by integrating molecular dynamics and co-evolutionary analysis [23] among the protein dynamical modules.

No.	Mutation sites	Module No.	Reference	No.	Mutation sites	Module No.	Reference
1	M251P	4	[23]	16	E346R	1	[23]
2	T253R	3	[23]	17	V347M	1	[39]
3	R305A	2	[23]	18	V349M	1	[39]
4	S315A	1	[23]	19	T352I	2	[23]
5	M318I	3	[39]	20	T355	3	-
6	H320A	2	[39]	21	C378	3	-
7	G323D	3	[39], [40]	22	I392	5	-
8	F324	1	-#	23	F407	3	-
9	L325F	2	[39]	24	N414	4	-
10	F329R	3	[23]	25	R416A	1	[23]
11	I337P	3	[23]	26	M417I	1	[39]
12	S338L	3	[23]	27	S423	2	-
13	V339A	2	[23]	28	S424	3	-
14	T344M	1	[40]	29	N426	3	-
15	S345L	1	[39], [40]	30	C428R	3	[23]

^#: Mutations of the corresponding positions have not yet been reported.