Table 4. Distribution of mutation sites predicted by integrating molecular dynamics and co-evolutionary analysis [23] among the protein dynamical modules.
| No. | Mutation sites | Module No. | Reference | No. | Mutation sites | Module No. | Reference |
| 1 | M251P | 4 | [23] | 16 | E346R | 1 | [23] |
| 2 | T253R | 3 | [23] | 17 | V347M | 1 | [39] |
| 3 | R305A | 2 | [23] | 18 | V349M | 1 | [39] |
| 4 | S315A | 1 | [23] | 19 | T352I | 2 | [23] |
| 5 | M318I | 3 | [39] | 20 | T355 | 3 | - |
| 6 | H320A | 2 | [39] | 21 | C378 | 3 | - |
| 7 | G323D | 3 | [39], [40] | 22 | I392 | 5 | - |
| 8 | F324 | 1 | -# | 23 | F407 | 3 | - |
| 9 | L325F | 2 | [39] | 24 | N414 | 4 | - |
| 10 | F329R | 3 | [23] | 25 | R416A | 1 | [23] |
| 11 | I337P | 3 | [23] | 26 | M417I | 1 | [39] |
| 12 | S338L | 3 | [23] | 27 | S423 | 2 | - |
| 13 | V339A | 2 | [23] | 28 | S424 | 3 | - |
| 14 | T344M | 1 | [40] | 29 | N426 | 3 | - |
| 15 | S345L | 1 | [39], [40] | 30 | C428R | 3 | [23] |
#
: Mutations of the corresponding positions have not yet been reported.