Table 7. Distribution of the residue numbers among different structural regions for each protein dynamical module of wild-type as well as mutations V339A and R305A.
Module No. | ||||||||
Mutation sites | Structural regions | 1 | 2 | 3 | 4 | 5 | 6 | 7 |
Wild-type | ACT1 | 17 | 13 | 23 | 13 | 12 | 0 | 0 |
ACT2 | 6 | 7 | 25 | 27 | 7 | 1 | 0 | |
C-lobe | 0 | 1 | 4 | 13 | 40 | 24 | 2 | |
N-lobe | 0 | 0 | 1 | 22 | 78 | 99 | 12 | |
V339A | ACT1 | 21 | 18 | 18 | 21 | 0 | 0 | 0 |
ACT2 | 7 | 14 | 26 | 19 | 7 | 0 | 0 | |
C-lobe | 0 | 0 | 4 | 32 | 29 | 18 | 1 | |
N-lobe | 0 | 0 | 3 | 28 | 109 | 70 | 2 | |
R305A | ACT1 | 25 | 22 | 14 | 13 | 4 | 0 | 0 |
ACT2 | 8 | 23 | 21 | 20 | 1 | 0 | 0 | |
C-lobe | 0 | 1 | 8 | 36 | 25 | 14 | 0 | |
N-lobe | 0 | 1 | 5 | 36 | 108 | 57 | 5 |