Table 1.
Summary of prostanoid receptors and associated intracellular signalling pathways with respect to platelets and vascular smooth muscle
| Prostanoid | Receptor | Signalling pathway | Vascular smooth muscle tone | Platelet reactivity |
|---|---|---|---|---|
| PGD2 | DP | ↑ Adenylyl cyclase | ↓ | |
| PGE2 | EP1 | ↑ IP3/DAG/Ca2+ | ↑ | |
| EP2 | ↑ Adenylyl cyclase | ↓ | ↓ | |
| EP3 | ↓ Adenylyl cyclase | ↑ | ↑ | |
| EP4 | ↑ Adenylyl cyclase | ↓ | ↓ | |
| IP | ↑ Adenylyl cyclase | ↓ | ↓ | |
| PGF2α | FP | ↑ IP3/DAG/Ca2+ | ↑ | |
| PGH2 | TP | ↑ IP3/DAG/Ca2+ | ↑ | ↑ |
| PGI2 | IP | ↑ Adenylyl cyclase | ↓ | ↓ |
| TXA2 | TP | ↑ IP3/DAG/Ca2+ | ↑ | ↑ |