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. 2011 Oct;72(4):672–682. doi: 10.1111/j.1365-2125.2010.03879.x

Figure 2.

Figure 2

Each molecule of fibrinogen can bind to two GP IIb-IIIa molecules. This leads to cross-linking/aggregation of platelets. The RGD sequence is pivotal to binding of fibrinogen that forms an initial more reversible complex (KD 150–180 nm) and a subsequent more stable complex with a KD of 20–70 nm