Fig. 1.

Structure of nuclear clusterin (nCLU). (A) Schematic view of the CLU protein. The human CLU gene is located on chromosome 8 and consists of nine exons. The secretory CLU transcript starts with the first ATG (amino acid [a.a.] residue 1) and that of nCLU starts with the second ATG (a.a. 34). The CLU protein has two coiled coil (CC) domains and the putative Bcl-2 homology 3 (BH3) motif (a.a. 316-336) is in CC2. LP, leader peptide. (B) Sequence homolog y of BH3 motifs among BH3-only proteins. The core BH3 sequences are underlined, and the highly conserved arginine (L) is in red. The BH3 motif is responsible for binding the anti-apoptotic Bcl-2 family, such as Bcl-2 and Bcl-XL.