Table 4.
Histologic findings in MARV virus inoculated animals.
| Animal number |
29003 |
29005 |
28554 |
29784 |
29015 |
29018 |
|---|---|---|---|---|---|---|
| Dose |
103PFU |
103PFU |
103PFU |
103PFU |
10 PFU |
10 PFU |
| Survival (days) | 8 | 7 | 8 | 7 | 6 | 7 |
| Liver | ||||||
| Hepatic necrosis | ++ | ++ | ++ | ++ | ++ | ++ |
| Hepatocellular dissociation | ++ | − | + | + | − | + |
| Neutrophilic infiltrates | + | + | + | + | + | + |
| Hepatocellular fatty change | ++ | − | + | + | + | |
| Adrenal | ||||||
| Extramedullary hematopoiesis | − | − | + | ++ | − | + |
| Adrenalitis/necrosis | + | + | + | + | ++ | + |
| Lung | ||||||
| Pneumonitis | − | − | + | + | + | − |
| Perioarteriolar edema | + | − | − | − | + | − |
| Spleen | ||||||
| Necrosis | ++++ | +++ | +++ | ++++ | + | ++ |
| Lymphocytic depletion | +++ | +++ | +++ | ++++ | + | ++ |
| Fibrin deposition medullary cords | ++ | ++ | ++ | ++ | + | + |
| Lymph node | ||||||
| Necrosis | ++ | − | n/a | + | − | − |
| Lymphocytic depletion | + | − | + | − | − | |
| Thymus | − | n/a | + | n/a | − | n/a |
| Bone marrow, kidney, heart, skeletal muscle, brain, gastrointestinal tissue | PMA | WNL | WNL | WNL | WNL | WNL |
− is absence of lesion; + is mildly affected ; ++ moderately affected; +++ severely affected WNL is within Normal Limits.