Table 4.
Animal number |
29003 |
29005 |
28554 |
29784 |
29015 |
29018 |
---|---|---|---|---|---|---|
Dose |
103PFU |
103PFU |
103PFU |
103PFU |
10 PFU |
10 PFU |
Survival (days) | 8 | 7 | 8 | 7 | 6 | 7 |
Liver | ||||||
Hepatic necrosis | ++ | ++ | ++ | ++ | ++ | ++ |
Hepatocellular dissociation | ++ | − | + | + | − | + |
Neutrophilic infiltrates | + | + | + | + | + | + |
Hepatocellular fatty change | ++ | − | + | + | + | |
Adrenal | ||||||
Extramedullary hematopoiesis | − | − | + | ++ | − | + |
Adrenalitis/necrosis | + | + | + | + | ++ | + |
Lung | ||||||
Pneumonitis | − | − | + | + | + | − |
Perioarteriolar edema | + | − | − | − | + | − |
Spleen | ||||||
Necrosis | ++++ | +++ | +++ | ++++ | + | ++ |
Lymphocytic depletion | +++ | +++ | +++ | ++++ | + | ++ |
Fibrin deposition medullary cords | ++ | ++ | ++ | ++ | + | + |
Lymph node | ||||||
Necrosis | ++ | − | n/a | + | − | − |
Lymphocytic depletion | + | − | + | − | − | |
Thymus | − | n/a | + | n/a | − | n/a |
Bone marrow, kidney, heart, skeletal muscle, brain, gastrointestinal tissue | PMA | WNL | WNL | WNL | WNL | WNL |
− is absence of lesion; + is mildly affected ; ++ moderately affected; +++ severely affected WNL is within Normal Limits.