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. Author manuscript; available in PMC: 2012 Nov 1.
Published in final edited form as: Cytotherapy. 2011 Aug 17;13(10):1269–1280. doi: 10.3109/14653249.2011.586997

Figure 6. In vitro effects of CTLA4-Ig and S5 (canine anti-CD44 mAb) alone and in combination on mixed lymphocyte culture immunoreactvity and NK cell activity.

Figure 6

(A) Mixed lymphocyte culture immunoreactivity of G053, G052 and E816 cells towards autologous cells (auto), DLA haploidentical cells (Haplo) (G052 against G053, and G053 against G052) and unrelated donor cells (URD) (G052 or G053 against E816, or E816 against G052 or G053) in the absence of CTLA4-Ig and S5 (Control), presence of CTLA4-Ig 10 μg/ml only (CTLA4-Ig), presence of S5 10 μg/ml only (S5), or presence of both CTLA4-Ig 10 μg/ml and S5 10 μg/ml (CTLA4-Ig and S5). Data are presented as mean and range of counts per minute (CPM) from triplicates. (B) The specific lysis of canine thyroid carcinoma cells by PMNC is presented as mean and range from 3 dogs (G053, G052 and E816). Abbreviations: ConA, concanavalin-A; E:T ratio, effector: to target cells ratio.