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. Author manuscript; available in PMC: 2012 Oct 1.
Published in final edited form as: Eur J Neurosci. 2011 Aug 22;34(8):1268–1275. doi: 10.1111/j.1460-9568.2011.07826.x

Figure 3. Mutant channels exhibit time dependent gating defects.

Figure 3

A) Time to peak current was analyzed from −30 mV to +30 mV. R859H exhibits a significantly delayed activation time in the voltage range −30 mV to 5 mV compared to Nav1.1 WT (Student’s t-test, WT n=13; R859H n=12, *P<0.05). B) Inactivation rate constants (current decay after peak INa) were obtained by fitting the inactivating sodium current with a double exponential to obtain two rate constants; fast and slow component. R859H showed an overall slowing in the speed of inactivation, while the R865G only showed an increase in a slow inactivation rate constant (Student’s t-test, *P<0.05; **P<0.005; †P=0.00095; WT n=13; R859H n=12; R865G n=10).