Effect of binge pattern cocaine on FST behavior. Rats were treated with vehicle (Veh, saline) or cocaine (Coc; 3×15 mg/kg/d, IP) for 2, 7, or 14 daysin a between-subject design (N=8 rats/group), and time to immobility was measured during a 15-min forced swim session 24 hr after the last cocaine treatment of the indicated day. Data are expressed as time (s) to become immobile (±SEM). **P<0.01 compared to vehicle-treated rats at the same time point;Simple main effects tests on treatment for each treatment day.