Table 1.

Definition of Metrics.

Metric	Definition
Trichotomized Best Response (Best TriTR)	Best objective status (CR/PR vs. Stable vs. Progression)
Confirmed Response	Two consecutive assessments of complete or partial response assessed at least 4 weeks apart (CR/PR vs. no CR/PR)
Trichotomized Response Status (TriTR) at a pre-defined timepoint	Objective status at the assessment closest to the pre-defined timepoint (CR/PR vs. Stable vs. Progression)
Total Sum of Measurements (TSM)	Sum of measurements at each assessment
Average Sum of Measurements (ASM)	Sum of measurements divided by the number of assessments
Relative change from baseline (RCB)	Sum of the relative changes since baseline, calculated as follows: divide the sum of measurements at each assessment by the sum of the baseline measurements and subtract 1; then sum this quantity over all assessments
Average relative change from baseline (ARCB)	RCB divided by the number of assessments