Table 2.
Echocardiographic measurements after 4 weeks of treatment
| WKY | SHR + moxonidine (µg·kg−1·h−1) | |||
|---|---|---|---|---|
| Echocardiographic parameters | 0 | 0 | 100 | 400 |
| ESD (mm) | 2.3 ± 0.0 | 2.7 ± 0.1 | 2.8 ± 0.2 | 2.9 ± 0.1 |
| EDD (mm) | 5.8 ± 0.1 | 5.6 ± 0.1 | 6.0 ± 0.0 | 5.8 ± 0.0 |
| AW (mm) | 1.7 ± 0.1 | 1.8 ± 0.1 | 1.7 ± 0.0 | 1.7 ± 0.1 |
| PW (mm) | 2.1 ± 0.1 | 2.3 ± 0.0 | 2.2 ± 0.1 | 2.1 ± 0.1 |
| RWT | 0.72 ± 0.04 | 0.83 ± 0.03* | 0.68 ± 0.06† | 0.68 ± 0.07† |
| ESV (mL) | 0.04 ± 0.00 | 0.06 ± 0.00* | 0.07 ± 0.01 | 0.08 ± 0.01 |
| EDV (mL) | 0.69 ± 0.04 | 0.63 ± 0.02 | 0.76 ± 0.04‡ | 0.70 ± 0.03 |
| Fractional shortening (%) | 60.4 ± 0.9 | 52.8 ± 0.7‡ | 54.1 ± 1.4 | 50.7 ± 1.8 |
| Ejection fraction (%) | 92.4 ± 0.4 | 91.3 ± 0.4 | 91.0 ± 0.7 | 88.5 ± 1.2 |
| Stroke index (mL·100 g−1) | 0.39 ± 0.02 | 0.29 ± 0.01* | 0.36 ± 0.02‡ | 0.35 ± 0.02‡ |
| Cardiac index (mL·min−1·100 g−1) | 124 ± 8 | 98 ± 6* | 98 ± 8 | 87 ± 5 |
| LVMPI | 0.17 ± 0.02 | 0.32 ± 0.02* | 0.31 ± 0.02 | 0.26 ± 0.02† |
*
P < 0.05 versus WKY
†
P < 0.05
‡
P < 0.01 versus corresponding vehicle.
AW, anterior wall; EDD, end diastolic diameter; EDV, end diastolic volume; ESD, end systolic diameter; ESV, end systolic volume; LVMPI, left ventricular myocardial performance index; PW, posterior wall; RWT, relative wall thickness; SHR, spontaneously hypertensive rats; WKY, Wistar-Kyoto.