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. 2011 Oct;164(3):992–1007. doi: 10.1111/j.1476-5381.2011.01390.x

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British Journal of Pharmacology © 2011 The British Pharmacological Society

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Simulations of receptor occupancy versus time profiles using the in vitro non-equilibrium binding kinetic k_on and k_off values (solid line), or k_on optimized fit (dashed line), superimposed on observed receptor occupancy data (). (A) DMP904, (B) R121919, (C) PF-4734666, (D) PF-4850890.

Inline graphic — Simulations of receptor occupancy versus time profiles using the in vitro non-equilibrium binding kinetic k_on and k_off values (solid line), or k_on optimized fit (dashed line), superimposed on observed receptor occupancy data (). (A) DMP904, (B) R121919, (C) PF-4734666, (D) PF-4850890.