Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Simulations of an 80 mg clinical dose of the CRF1 antagonist, R121919 (see text for details). Solid line represents a simulation using the in vitro derived parameters, whereas the dotted and dashed lines represent a fivefold increase and decrease of kon respectively.
