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. 2011 Oct 18;5:123. doi: 10.3389/fnins.2011.00123

Figure 5.

Figure 5

Binding profile of [3H]EBOB in HAD rats microinfused with PBS (n = 10) or pHSVsiLA1 (n = 10) at 72 h post-infusion. (A) Saturation isotherm shows significant differences in specific binding between the two groups [F(3, 312) = 107, P < 0.0001]. A Tukey post hoc test detected that [3H]EBOB binding (B max) was reduced from 861 ± 16 to 554 ± 8 fmol/mg protein in control and pSHVsiLA1-treated rats, respectively, with no significant change in affinity (Kd; control, 2.67 ± 0.24 nM; pHSVsiLA1-treated, 2.70 ± 0.18 nM). (B) Scatchard analysis of [3H] EBOB binding to GABAA receptors in VP of PBS- (n = 10) or pHSVsiLA1- (n = 20) treated rats.