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(A) HP 13C MRSI grids superimposed to anatomical images acquired from one Everolimus treated animal at D0 (left) and D7 (right). The tumor voxels (>80% of tumor tissue) are presented as bold boxes. (B) Corresponding HP 13C MRSI spectra. (C) HP 13C spectra from the tumor voxels of interest and corresponding values of (Lactate/Pyruvate)TUMOR and (Lactate/Pyruvate)NORMALIZED. A decrease in the (Lactate/Pyruvate)TUMOR ratio can clearly be observed after 7 days of Everolimus treatment.
