Figure 4.

HDX data overlaid onto a modified crystal structure (see Figure 1 legend) for β₂AR. The HDX data is shown using color gradients where the differences in the average % deuterium uptake across all time points between the apo and ligand bound receptor for peptides in a given region of the receptor sequence are assigned a color as shown in the key, and then overlaid onto the structure. Here, white indicates regions of the receptor that were not resolved in the HDX experiment, and gray indicates no significant change. Ligand structures are indicated above the structures.