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Neutralization of titratable residues near F168E. A, molecular model of the bundle crossing region of Kir6.2. B–E, double mutants Kir6.2(H70A/F168E) (n = 7), Kir6.2(F168E/K170A) (n = 7), and Kir6.2(F168E/H175A) (n = 5) were examined for pH dependence. All double mutants exhibited alkalization-dependent activation comparable with Kir6.2(F168E) channels.
