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. 2011 Aug 24;286(42):36414–36426. doi: 10.1074/jbc.M111.282822

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© 2011 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 1. — Assembly of the replication fork helicase. A, Sld3-Cdc45 binds to Mcm2–7 at early origins in G₁ (29). Sld3 blocks the interaction between GINS and Mcm2–7, thereby inhibiting premature activation of the helicase (36). B, the Mcm2–7 ring opens (8, 37). C, exposure of thymines in origin ssDNA promotes the association of Sld3 with origin ssDNA (38). D, interaction between Sld3 and ssDNA dissociates Sld3 from Mcm2–7, allowing GINS to bind to Mcm2–7 (38). E, CMG complex unwinds DNA ahead of the replicative polymerases (7, 9, 10).