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. 2011 Aug 5;286(42):36841–36851. doi: 10.1074/jbc.M111.220061

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© 2011 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 5. — Increased vessel permeability in angptl4-deficient pups. A, leakage of Evans Blue in P7 angptl4^+/LacZ and angptl4^LacZ/LacZ retinas. Values are expressed as % of the control (angptl4^+/LacZ) value, (angptl4^+/LacZ, n = 4; angptl4^LacZ/LacZ, n = 5). B and G, confocal images of whole mount P7 angptl4^+/LacZ and angptl4^LacZ/LacZ retinas stained with IB4 (blue) and ZO-1 (red). Prior to sacrifice, fluorescent 100 nm microspheres were injected intravenously and flushed from circulation 15 min afterwards. B and C, deconvolution and three-dimensional reconstruction of the boxed region in E. Extravasated microspheres are trapped around tight junctions with a large part outside of the vessel (ZO-1, red). Field dimensions are 200 × 220 × 7 μm. E and G, extravasated microspheres (green) were only observed in angptl4^LacZ/LacZ retinas. Scale bar = 100 μm. n = 6 per group. p < 0.05.