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Gene regulation by FoxO and E-box transcription factors downstream of PI 3-kinase/Akt/GSK3 signaling. E-box sequences (black boxes) and FoxO-binding sites (white boxes) are shown in 1 kb upstream of the transcription start site (TSS) for ATROGIN-1, CCNG2, and TXNIP. The E-box and FoxO-binding sites are those as analyzed in Figs. 1–5. The E-box and FoxO transcription factors that regulate expression of each the indicated target genes are shown, as discussed in the text.
