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. 2011 Aug 5;286(42):36163–36170. doi: 10.1074/jbc.M111.228817

FIGURE 4.

FIGURE 4.

Insulin-stimulated glucose uptake in muscle and white adipose tissue, insulin-stimulated AKT2 activity in muscle, and plasma IGFBP-3 levels in Alb:GC Tg and WT littermate control mice. A, insulin-stimulated 2-deoxyglucose (2-DOG) uptake by the gastrocnemius muscle was decreased in Alb:GC Tg mice compared with the WT mice at the end of the hyperinsulinemic-euglycemic clamp (n = 6–8/group). B, insulin-stimulated 2-deoxyglucose uptake by white adipose tissue (WAT) was reduced in Alb:GC Tg mice compared with the WT mice at the end of the hyperinsulinemic-euglycemic clamp (n = 6/group). C, insulin-stimulated Akt2 activity in gastrocnemius muscle was reduced in Alb:GC Tg mice compared with WT mice at the end of the hyperinsulinemic-euglycemic clamp (n = 5/group). D, plasma IGFBP-3 concentrations were increased in the Alb:GC Tg mice (n = 6/group). E, Smad-2 phosphorylation was increased in skeletal muscle of Alb:GC Tg mice (n = 5).