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Proposed model shows the requirement of the IL-4Rα-Jak2-mediated signaling pathway for IL-13-induced M2 gene expression in human monocytes/macrophages. IL-13 stimulates the Src kinase Hck via the IL-4Rα-Jak2-dependent signaling pathway leading to the activation of the Hck-MKK3/6-p38 MAPK signaling cascade. Consequently Stat1 and Stat3 are maximally activated, and gene expression of 15-LO, mannose receptor, MAO-A, and CD36 is induced.
