TABLE 2.
Organ | Metabolites | Bhmt+/+ | Bhmt−/− |
---|---|---|---|
Liver | AdoMet (nmol/g tissue) | 76.4 ± 3.7 | 43.5 ± 5.7a |
AdoHcy (nmol/g tissue) | 21.8 ± 1.7 | 54.4 ± 7.7a | |
AdoMet:AdoHcy | 3.6 ± 0.2 | 0.9 ± 0.1a | |
tHomocysteine (nmol/g tissue) | 4.2 ± 0.3 | 26.5 ± 5.5a | |
Methionine (nmol/g tissue) | 223 ± 26 | 242 ± 23 | |
Dimethylglycine (nmol/g tissue) | 48.2 ± 19.0 | 2.2 ± 0.2a | |
Methylglycine (nmol/g tissue) | 20.2 ± 8.9 | 52.7 ± 12.2b | |
Cystathionine (nmol/g tissue) | 32.0 ± 15.7 | 20.3 ± 5.8 | |
Cysteine (nmol/g tissue) | 247 ± 25 | 291 ± 25 | |
Glycine (nmol/g tissue) | 1,659 ± 128 | 1,561 ± 135 | |
Plasma | tHomocysteine (μm) | 6.5 ± 0.7 | 50.8 ± 5.9a |
Cysteine (μm) | 131.1 ± 9.9 | 68.4 ± 9.3a | |
tFolate (ng/ml) | 81.7 ± 6.4 | 52.8 ± 5.1a |
a p < 0.01, different from Bhmt+/+ by Student's t test.
b p < 0.05, different from Bhmt+/+ by Student's t test.