Comparison of the surface charge of ForC GBD (A) with those of other known or putative GTPase-binding proteins, including Ral-GDS GBD (Protein Data Bank code 1lxd) (B), talin F0 domain (Protein Data Bank code 2kc1) (C), and FHOD1 GBD (Protein Data Bank code 3dad) (D). For each protein, a ribbon representation is shown on the left, and a surface representation in two views is shown on the right. Arginine and lysine side chains and positively charged surface patches are colored blue, and glutamate and aspartate side chains and negatively charged surface regions are shown in red.