Fig. 2.

Hepatic VLDL production by Pla2g1b^+/+ and Pla2g1b^−/− mice. The Pla2g1b^+/+ (filled symbols; WT) and Pla2g1b^−/− (open symbols; KO) mice were fed basal chow diet (panel A, from five Pla2g1b^+/+ and three Pla2g1b^−/− mice) or a hypercaloric diet for two (panel B, from nine Pla2g1b^+/+ and eight Pla2g1b^−/− mice) or seven weeks (panel C from six Pla2g1b^+/+ and seven Pla2g1b^−/− mice). The mice were fasted for 12 h, and then received an intraperitoneal injection of Poloxamer 407 (1 g/kg body weight). Plasma samples were obtained at hourly intervals for triglyceride measurements. The left panels show time-dependent increases in plasma triglyceride levels, and the right panels show AUC analyses of the respective data. Results represent mean ± SE, *P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001 versus Pla2g1b^+/+ mice.