Table 1.
Selected targets of ZEB1 and ZEB2 during EMT*
| ZEB1 | ZEB2 | |
|---|---|---|
| Direct Transcriptional Targets | Genes downregulated | Genes downregulated |
| E-cadherin [41,66,68,69] Crumbs3, HUGL2, PATJ [6] Paklophilin 3 [74] MMP1 [102] miR-200 family [88, 89] | E-cadherin [67] P-cadherin [75] Claudin 4 [75] Connexin 26 [75] miR-200 family [89] | |
| Genes upregulated | ||
| Vimentin [76] | ||
| Indirect Targets or Unknown Mechanism | Genes downregulated | Genes downregulated |
| P- & R-Cadherin [6] Occludin & JAM1 [6] Desmocollin-2 [6] Gap junction protein β2 & β3 [6] Epiplakin & Periplakin [6] Mucin [6] EpCAM [6,65] ESRP1/2 & ST14 [65] | ZO-3 [75] Plakophilin 2 & Desmoplakin 1/2 [75] Connexin 31 [75] Gap junction protein β2 & β3 [75] EpCAM [65] ESRP1/2 & ST14 [65] | |
| Genes upregulated | Genes upregulated | |
| Vimentin [68,69] | Fibronectin (77) MMP1, MMP2, MMP14 [77] |
*
Note that being a direct transcriptional target of ZEB1 and/or ZEB2 does not exclude indirect regulation as well. Genes under the label indirect target/unknown mechanism refer to those that are either known to be regulated by ZEB1 and/or ZEB2 exclusively through indirect mechanisms or where direct binding of ZEB1 and/or ZEB2 to their regulatory regions has not been demonstrated yet. Numbers in brackets refer to the references where these targets were identified.