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Synthesis of Class Ib prodrugs 10 (Top)a and 14 (Bottom)b.
aConditions: (a) isobutyryl chloride, Et3N, CH2Cl2, rt, 16 h; (b) 4, benzene, reflux, 0.5 h; (c) SnCl2•2H2O, MeCN, reflux, 1.5 h.
bConditions: (a) isobutyryl chloride, Et3N, CH2Cl2, rt, 1 h; (b) benzene, reflux, 20 min; (c) H2 (50 psi), Pd/C, EtOAc, rt, 14 h.
