TABLE 4.
VAS changes: p-value and mean percent change from baseline
| FACIAL SKIN ATTRIBUTE | WEEK 4 VS. BASELINE (MEAN % CHANGE FROM BASELINE)‡ | WEEK 7 VS. BASELINE (MEAN % CHANGE FROM BASELINE)‡ | WEEK 10 VS. BASELINE (MEAN % CHANGE FROM BASELINE)‡ | WEEK 13 VS. BASELINE (MEAN % CHANGE FROM BASELINE)‡ | ||||
|---|---|---|---|---|---|---|---|---|
| Peel + RA | Peel | Peel + RA | Peel | Peel + RA | Peel | Peel + RA | Peel | |
| FINE LINES | ns (−1.7%) | ns (−6.5%) | ns (−14.5%) | s (−20.0%) | s (−19.3%) | s (−26.5%) | s (−23.5%) | s (−30.4%) |
| WRINKLES | ns (−4.8%) | ns (−3.4%) | ns (−10.3%) | ns (−115.6%) | ns (−17.1%) | s (−22.9%) | ns (−19.9%) | s (−23.9%) |
| RADIANCE | ns (−0.2%) | ns (−0.4%) | ns (−3.3%) | ns (−11%) | ns (−18.9%) | ns (−16.7%) | s (−24.1%) | s (−23.8%) |
| ROUGHNESS | ns (−8.2%) | ns (−15.6%) | s (−24.2%) | s (−27.6) | s (−26.1%) | s (−30.8%) | s (−33.4%) | s (−33.7%) |
| SKIN TONE EVENNESS* | 0.0692† (ns) (−21.9%) | 0.1149† (ns) (−19.1%) | 0.0021† (s) (−32.1%) | 0.0018† (s) (−32.9%) | 0.0004† (s) (−37.3%) | 0.0010† (s) (−36.2%) | <0.0001† (s) (−43.3%) | 0.0003† (s) (−37.7%) |
| SKIN TONE CLARITY | ns (−21.1%) | s (−24.9%) | s (−35.0%) | s (−40.2%) | s (−34.6%) | s (−42.6%) | s (−38.3%) | s (−45.0%) |
| FIRMNESS | ns (−10.2%) | ns (−19.4%) | ns (−11.4%) | ns (−12.2%) | ns (−14.7%) | ns (−22.8%) | ns (−18.7%) | s (−24.6%) |
| PORE APPEARANCE | ns (−-15.2%) | ns (−16.1%) | ns (−22.7%) | ns (−17.3%) | ns (−19.0%) | ns (−25.5%) | ns (−23.6%) | ns (−26.8%) |
| HYPERPIGMENTATION* | 0.6359† (ns) (−21.0%) | 1.0956† (ns) (−21.0%) | 0.0235† (s) (−36.7%) | 0.1108† (ns) (−34.0%) | 0.0041† (s) (−42.6%) | 0.0008† (s) (−47.3%) | 0.0033† (s) (−43.8%) | 0.0049† (s) (−45.0%) |
*
Kruskal Wallis with Bonferroni test, used where Shapiro-Wilk Test P>0.05
†
P value.
‡
(100) (Posttreatment mean—baseline mean)/baseline mean
- VAS
Visual Analog Scale
- RA
retinoic acid.
- s
significant
- ns
not significant