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. Author manuscript; available in PMC: 2011 Oct 18.
Published in final edited form as: Am J Rhinol Allergy. 2009 May-Jun;23(3):294–299. doi: 10.2500/ajra.2009.23.3316

Figure 1.

Figure 1

Stimulation of transepithelial Cl secretion by L-ascorbate in sinus tissue excised from normal human subject. Transepithelial Cl currents (ICl) across sinus epithelia were measured in the presence of the sodium channel blocker Amiloride (10 µM) and a serosal-to-mucosal directed Cl gradient (−Clmuc). A: Time control experiment. Without adding L-ascorbate, there was no increase in ICl. B: L-ascorbate (500 µM) applied to the mucosal surface stimulated ICl in a sustained fashion and subsequent addition of the cAMP agonist forskolin (20 µM) further stimulated ICl, whereas Cl transport inhibitors (Glibenclamide, Bumetanide) significantly reduced the ascorbate- and forskolin stimulated ICl.