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. Author manuscript; available in PMC: 2011 Oct 18.

Published in final edited form as: Am J Rhinol Allergy. 2009 May-Jun;23(3):294–299. doi: 10.2500/ajra.2009.23.3316

Stimulation of transepithelial Cl secretion by L-ascorbate in sinus tissue excised from patients with chronic rhinosinusitis (CRS). A: Effective stimulation of gradient-driven Cl current (I_Cl) by 500 µM L-ascorbate in amiloride-treated CRS sinus tissue and subsequent inhibition by Cl transport inhibitors (Glibenclamide, Bumetanide). B: Summary of data obtained from seven CRS tissue specimens. I_Cl before and after exposure to L-ascorbate (500 µM) for 15–30 minutes. Each paired specimen is connected by a line (P < 0.05, Paired Sample t test).

Stimulation of transepithelial Cl secretion by L-ascorbate in sinus tissue excised from patients with chronic rhinosinusitis (CRS). A: Effective stimulation of gradient-driven Cl current (I_Cl) by 500 µM L-ascorbate in amiloride-treated CRS sinus tissue and subsequent inhibition by Cl transport inhibitors (Glibenclamide, Bumetanide). B: Summary of data obtained from seven CRS tissue specimens. I_Cl before and after exposure to L-ascorbate (500 µM) for 15–30 minutes. Each paired specimen is connected by a line (P < 0.05, Paired Sample t test).