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. Author manuscript; available in PMC: 2011 Oct 18.
Published in final edited form as: Am J Rhinol Allergy. 2009 May-Jun;23(3):294–299. doi: 10.2500/ajra.2009.23.3316

Figure 5.

Figure 5

Changes in chloride currents (ΔICl) in normal and CRS sinonasal tissue. The magnitude of ascorbate-stimulated Cl currents and Cl currents blocked after addition of Cl transport inhibitors (glibenclamide, bumetanide) are plotted from individual experiments and average values are shown as horizontal bars. At 1 mM L-ascorbate, the ΔICl of sinus mucosa from CRS equaled the ΔICl observed in normal sinus epithelia at 500 µM L-ascorbate (p > 0.05). However, the ΔICl of nasal mucosa from CRS at 1 mM L-ascorbate was still decreased to the ΔICl observed in normal nasal epithelia at 500 µM L-ascorbate (p < 0.05). At maximal stimulation with a combination of 1 mM L-ascorbate and forskolin, the ΔICl of nasal mucosa from CRS was increased when compared to the response observed in normal nasal epithelia at 500 µM L-ascorbate (p > 0.05). #: denotes a significant difference (p < 0.05). ●: Normal epithelia. ○: Diseased epithelia.