Fig. 2.
Time-course and dose–response effects of acute administration of kynurenine metabolites on activity of the rat liver mitochondrial low km ALDH activity was determined as described in the ‘Materials and Methods’ section at various times after intraperitoneal administration of a 10 mg/kg dose of kynurenine metabolites (a) or at 1 h after 1–10 mg/kg doses (b). Values are means ± SEM (bars) for each group of 4–5 rats. Values at the different time-intervals were compared statistically (t-test) with those at zero time, whereas those with various doses were compared with the zero-dose saline control, and the significance of the differences is expressed in the relevant text of the ‘Results’ section. Abbreviations used: ALDH, aldehyde dehydrogenase; KA, kynurenic acid; 3-HK, 3-hydroxykynurenine; 3-HAA, 3-hydroxyanthranilic acid.