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. Author manuscript; available in PMC: 2012 Oct 15.
Published in final edited form as: Cancer Res. 2011 Aug 30;71(20):6350–6359. doi: 10.1158/0008-5472.CAN-11-2025

Figure 2.

Figure 2

Tumor pO2 and blood volume imaging before and after anti-angiogenic treatment initiated at the later stage of tumor. (A) Initiation of anti-angiogenic treatment at the later stage of tumor improved tumor oxygenation (top row) and reduced tumor blood volume (bottom row) without a significant change in tumor size. (B–C) Frequency histograms (percentage of voxels with a given pO2 and blood volume) before and 4 days after anti-angiogenic treatment showed a clear right shift in pO2, but a shift in blood volume. (D) Quantitation of pO2 changes in sunitinib treated and control mice. *P <0.05. (E) Tumor blood volume decreased ~45% 4 days after treatment initiated at the later stage of tumor.