Figure 3.

Voxel-based trace of changes in (A) tumor pO₂ and (B) blood volume of representative 2 mice, where the tumor size and shape were the same before and 4 days after sunitinib treatment initiated 10 days after tumor implantation. (C) Scatter plots of pO₂ vs. blood volume in before (left column) and sunitinib treated (right column) mice. The data were classified into four groups: 1) pO₂ >10 mmHg before and after 4 days sunitinib treatment (black symbols), 2) pO₂ <10 mmHg before and after treatment (red), 3) pO₂ <10 mmHg before and pO₂ >10 mmHg after treatment (blue), 4) pO₂ >10 mmHg before and pO₂ <10 mmHg after treatment (green).