Fig. 6.

Comparison of fold regulation of NF-κB signaling in human respiratory and ocular cells relative to virus subtype. HCEpiC or Calu-3 cells were infected with influenza viruses at an MOI of 2. Total RNA was isolated from cells at 24 h p.i. and examined by real-time RT-PCR array analysis. Genes included in this analysis possessed the highest (A to C) or lowest (D to F) fold expression over that in mock-infected cells relative to virus subtype in Calu-3 cells (black), HCEpiC cultures (dark gray), or both cell types (light gray). Genes where virus infection did not result in a ≥3-fold change in expression over that in mock-infected cells within that cell type or where this fold change was not significant were excluded from this analysis.