Fig. 1.

(A) LAT in situ hybridization (dark nuclear staining) and anti-CD3 immunohistochemistry (brown surface staining) on a 4-μm paraffin section of human TG. All four different T-cell neuron interactions are depicted in this micrograph. Scale bar, 50 μm. (B) Percentage of neuronal patterns in latently HSV-1 infected human TG with range. The values are given as means ± the SEM of the total neurons of one TG section. All bars exhibit highly significant differences (Student t test: P < 0.005). (C) Percentage of neurons surrounded by T cells in latently HSV-1- or VZV-infected TG versus noninfected human TG. The difference in the percentage of neurons surrounded by T cells in latently HSV-1-infected ganglia versus non-HSV-1-infected ganglia is significant (Student t test, P = 0.001), whereas this is not the case with VZV-infected versus noninfected ganglia (Student t test, P = 0.472).