Table 1.
MAb | V heavy chain |
V light chain |
|||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
V | Db | J | HCDR3 lengtha | Mutation frequency | Isotype | V | J | κ/λ | LCDR3 lengtha | Mutation frequency | |
CH01 | 3-20 | 3-10 | 2 | 24 | 0.133 | IgG1 | 3-20 | 1 | κ | 9 | 0.100 |
CH02 | 3-20 | 3-10 | 2 | 24 | 0.143 | IgG1 | 3-20 | 1 | κ | 9 | 0.137 |
CH03 | 3-20 | 3-10 | 2 | 24 | 0.120 | IgG1 | 3-20 | 1 | κ | 9 | 0.106 |
CH04 | 3-20 | 3-10 | 2 | 24 | 0.115 | IgG1 | 3-20 | 1 | κ | 9 | 0.094 |
The HCDR3 and LCDR3 lengths are expressed as numbers of amino acids and reported according to the numbering system of Kabat et al. (20).
The D region may have resulted from the D-D fusion of the 3-10 gene segment with one of several other D gene segments.