Table 1.
Characteristics of Indian-origin rhesus monkeys exposed to SIV via the penis
| TRIM5α genotype | Monkey ID | TRIM5 allelesa | Infection status | No. of infected monkeys in group/no. of exposed monkeys (%) | No. of lineagesb | Homogeneous by Poissonc |
|---|---|---|---|---|---|---|
| Homozygous restrictive | AZ43 | 3, 3 | No | 0/6 (0) | NDd | ND |
| FB2B | 1, 1 | No | ND | ND | ||
| T8056 | 1, 4 | No | ND | ND | ||
| AZ40 | 4, 4 | No | ND | ND | ||
| AZ63 | 1, 3 | No | ND | ND | ||
| AZ88 | 2, 2 | No | ND | ND | ||
| Heterozygous permissive | 4236 | 2, 11 | Yes | 5/6 (83) | 2 | No |
| AV33X | 1, 6 | Yes | 1 | No | ||
| T8023 | 2, 8 | No | ND | ND | ||
| AV48 | 2, 7 | Yes | 4–6 | No | ||
| 7F8 | 1, 8 | Yes | 1 | Yes | ||
| 9E9 | 1, 7 | Yes | 1 | Yes | ||
| Homozygous permissive | DBFX | 6, 6 | No | 5/6 (83) | ND | ND |
| DBJL | 6, 7 | Yes | 1 | Yes | ||
| DBME | 7, 9 | Yes | 1 | Yes | ||
| DBGJ | 11, 11 | Yes | 1 | Yes | ||
| DBMT | 7, 11 | Yes | 1 | Yes | ||
| 8E9 | 7, 7 | Yes | 1 | Yes |
a
Diploid TRIM5 alleles were sequenced and numbered as described previously (22).
b
Minimum number of transmitted forms indicated by distinct lineages in the phylogenetic tree.
c
Homogeneous infection indicates that mutations fit a Poisson model of random accumulation in early infection. As observed for early HIV-1 infections, APOBEC mutations were enriched in some animals and excluded for analysis in all but two monkeys (7F8 and DBMT). AV33 appeared as a single lineage in the tree, but a violation of the Poisson model indicates that it may have been infected with multiple highly similar strains.
d
ND, not determined since the animal was not infected.