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. 2011 Oct;85(19):9956–9963. doi: 10.1128/JVI.00097-11

Fig. 6.

Fig. 6.

Amino acids 369 and 446 determine TRIMCyp restriction activity. (A) Anti-HA immunoblot of control and mutagenized TRIMCyp-expressing CrFK cell lines. (B) Restriction activity against HIV-1 NL4-3. (C) Restriction activity against HIV-2 ROD. (D) Restriction activity against FIV. Genotypes at amino acid positions 369 and 446 are shown, as described in the legend of Fig. 5. Data shown are means ± standard deviations from three independent experiments using one representative dilution of virus (11 ng RT/well for HIV-1 and HIV-2 and 33 ng RT/well for FIV). wt, wild type.