Fig. 1.
Age-dependent death induced by the intracranial inoculation of 1.0 × 106 TCID50 HSV-1 YK333 in Wistar GALAS rats. The inoculation of rats younger than 10 days old resulted in 100% mortality (groups composed of 5-day-old rats [n = 7], 7-day-old rats [n = 7], and 10-day-old rats [n = 5]). The inoculation of 14-day-old rats resulted in a survival rate of 50% (n = 40). Rats older than 18 days of age showed a survival rate of 100% (groups composed of 18-day-old rats [n = 7], 21-day-old rats [n = 7], and 28-day-old rats [n = 7]).