Table 3.
Multivariable Cox models stratified by study*
| Factor | No. | OS |
RFS |
RFI |
|||
| HR (95% CI) | P† | HR (95% CI) | P† | HR (95% CI) | P† | ||
| Cancer stage‡ | <.001 | <.001 | <.001 | ||||
| II | 4792 | 1.00 (referent) | 1.00 (referent) | 1.00 (referent) | |||
| III | 9819 | 1.97 (1.85 to 2.10) | 1.96 (1.84 to 2.08) | 2.56 (2.37 to 2.75) | |||
| Sex | <.001 | <.001 | 0.27 | ||||
| Women | 6697 | 1.00 (referent) | 1.00 (referent) | 1.00 (referent) | |||
| Men | 7914 | 1.18 (1.12 to 1.25) | 1.14 (1.08 to 1.20) | 1.03 (0.98 to 1.10) | |||
| Age, y | <.001 | <.001 | 0.40 | ||||
| <50 | 2708 | 1.00 (referent) | 1.00 (referent) | 1.00 (referent) | |||
| 50–59 | 3996 | 1.14 (1.04 to 1.24) | 1.09 (1.00 to 1.18) | 1.00 (0.91 to 1.08) | |||
| ≥60 | 7907 | 1.52 (1.41 to 1.65) | 1.32 (1.23 to 1.42) | 0.96 (0.88 to 1.03) | |||
| Race | <.001 | 0.0045 | 0.15 | ||||
| White | 13 393 | 1.00 (referent) | 1.00 (referent) | 1.00 (referent) | |||
| Black | 1218 | 1.22 (1.11 to 1.34) | 1.14 (1.04 to 1.24) | 1.08 (0.97 to 1.19) | |||
*
Multivariable analyses of OS, RFS, and RFI stratified by study and controlling for sex, stage, age, and treatment (data for treatment not shown) to determine the effect of race. CI = confidence interval; HR = hazard ratio; OS = overall survival; RFS = recurrence-free survival; RFI = recurrence-free interval.
†
P values were calculated using a two-sided Wald test.
‡
Stage II: tumor penetrates beyond the muscularis propria but no lymph node invasion and no other metastases. Stage III: lymph node invasion but no other metastases.