Table 2. Foci with significant changes in degree differences from non-drug users(NDUs) versus chronic heroin users(CHUs).

Regions of interest		Brodmann	MNI			NDU Degree	CHU Degree	p
		Area	x	y	z	mean ± sd	mean ± sd	value
Inferior Frontal Gyrus (IFG)	L	10/46/47	−15	18	−24	17.4±22.8	80.9±68.5	0.008
	R		39	25	6	42.2±45.4	116.1±88.9	0.03
Medial Frontal Gyrus (medFG)	L	32/9	−3	42	31	47.8±33.4	127±76.8	0.007
	R		3	42	31	41.4±27	103.6±67.9	0.01
Middle Frontal Gyrus (MFG)	L	10/9/6	−45	54	−6	25.1±22.2	176.6±79.3	0.002
	R		27	−12	48	25.5±36.7	133±95	0.004
Superior Frontal Gyrus (SFG)	L	10	−27	60	6	32±36	140.7±131.3	0.012
	R
Anterior Cingulate Cortex (ACC)	L	24/25	−3	30	12	98.3±57.6	28.3±39	0.004
	R		3	30	12	97.5±43.8	25±30.2	0.0003
Middle Cingulate Cortex (MCC)	L	24/32/31	−15	24	36	2.1±2.4	43±35.2	0.002
	R		21	−18	41	7.8±13.6	58.3±38.7	0.001
Posterior Cingulate Cortex (PCC)	L	23/30/31	−21	−66	6	337.9±297.6	108.9±93.8	0.02
	R		3	−66	12	332.3±299.3	100.8±57.8	0.02
Parahippocampal (PH)	L		−21	−54	0	255.7±188.5	65.5±58.1	0.004
	R		27	−48	−6	273.6±215.3	78±53.7	0.008
Hippocampus (HIP)	L
	R		27	−12	−19	184.6±170.6	25±26.9	0.006
Amygdala (AMY)	L
	R		21	0	−18	123±140.7	31.1±29.4	0.048
Insula (INS)	L		−39	−12	12	37.2±33.1	131.2±129.2	0.038
	R		39	−36	18	16.9±26.8	86.9±89.2	0.028
Thalamus (THA)	L		−15	−30	11	47.7±37.4	11.5±19.1	0.01
	R
Caudate (CAU)	L		−15	18	12	20.3±26.7	93±61	0.002
	R		9	12	12	62.4±29.2	24.7±26.5	0.006
Putamen (PUT)	L		−21	6	6	35.8±16.2	97.7±70.2	0.01
	R		27	−12	12	25±22.8	102.9±61.7	0.001
Pallidus (PAL)	L		−15	−6	−6	39.3±45.3	90±48.2	0.02
	R		21	−6	6	18±15.5	90.5±73.8	0.006
Fusiform (FFG)	L		−51	−42	−24	278.9±181.6	102.3±91.7	0.01
	R		51	−60	−18	336.1±217.1	101.6±86	0.003
Temporal Cortex	L		−63	−36	−18	220.2±157.3	60.6±56	0.005
	R		57	12	−24	235.7±179.5	29±25.2	0.001
Occipital Cortex	L		−39	−96	0	2.7±6	44.9±31.7	0.0005
	R		15	−90	12	290.3±195.1	65.3±48.3	0.001
Cerebellum	L		−9	−48	0	278.1±70.6	83.5±60.3	0.01
	R		9	−48	0	272.8±108.3	89.5±54.1	0.01