Figure 5. ER stress is mainly localized in epithelial secretory cells.

Immunohistochemical analysis of HSPA5, a central mediator of ER stress, was performed on paraffin embedded slides of A. colonic controls, B. inflamed areas of colonic Crohn's disease (CD) patients, C. inflamed areas of ulcerative colitis patients, D. ileal controls and E. inflamed areas of ileal CD patients. The ER stress observed is linked to the epithelium rather than to recruited inflammatory cells.