Table 1. Summary of the significant differences in the open field activity of MPS IIIA mice in the literature.
Paper | Hemsley et al. | Hemsley et al. | Lau et al. | Lau et al. | McIntyre et al. | Crawley et al. | * Hemsley et al. | * Hemsley et al. | * McIntyre et al. | * Fraldi et al. | This Study | |||||
Year | 2005 | 2007 | 2008 | 2010 | 2010 | 2006 | 2007 | 2009 | 2010 | 2007 | ||||||
Background | Mixed | Mixed | C57BL/6 | C57BL/6 | C57BL/6 | C57BL/6 | Mixed | C57BL/6 | C57BL/6 | C57BL/6 | C57BL/6J | |||||
Measure | Line Crossing | Line Crossing | Zone Entries | Path Length | Line crossing | Line Crossing | Line Crossing | Path Length | Line crossing | Path Length | Path Length | |||||
Sex | Male | Female | Male | Male | Female | Male | Male | Male | Female | Male | Male | Male | Male | Male | Female | |
Age (Weeks) | 3 | Hyper | Hyper | NS | NS | |||||||||||
4 | NS | Hypo | ||||||||||||||
5 | NS | NS | ||||||||||||||
6 | Hypo | NS | Hypo | NS | NS | |||||||||||
8 | NS | NS | NS* +Hypo* | |||||||||||||
10 | NS | NS | Hypo | NS | NS | NS | NS* | |||||||||
12 | Hyper | NS | NS* +Hypo* | Hypo* | ||||||||||||
15 | Hypo | NS | NS | NS | Hypo | NS | NS | NS* | ||||||||
16 | NS | Hyper | ||||||||||||||
18 | Hypo | NS | NS | NS | Hypo* | NS* | ||||||||||
20 | NS | NS | Hypo | NS* | ||||||||||||
21 | Hyper* | |||||||||||||||
22 | Hypo | NS | NS | Hyper | ||||||||||||
24 | NS | NS* | NS | Hyper | ||||||||||||
25 | NS | NS | ||||||||||||||
28 | NS | NS* | ||||||||||||||
32 | NS | Hyper | NS | Some Hyper | ||||||||||||
40 | NS | NS | NS | NS |
Hyper indicates significant hyperactive behaviour and hypo indicates significant hypoactive behaviour in the open field test. NS indicates no significant difference and * indicates mice that have recieved intracranial injections. Control injections contained: 2.5 µl of 50 mM sodium acetate, 100 mM sodium chloride at pH 5.0 in Hemsley et al 2007, 4 µl 10 mM sodium phosphate, 140 mM sodium chloride pH 7.0 in Hemsley et al. 2009, 5 µl 0.9% (w/v) sodium chloride in McIntyre et al. 2010 and 1 µl GFP adeno-associated viral vector in Fraldi et al. 2007. The work of Hemsley et al. 2007 contained multiple control treated groups and where there were differences between groups, both have been shown. Where female mice are not mentioned or cells are blank no testing was performed.