Figure 3. In vivo antitumor effect of ICOVIR5-TK-L+GCV administered locally or systemically.

(A) Nude mice bearing BxPC-3 subcutaneous xenografts were treated with saline, Adwt-RGD or ICOVIR5-TK-L+GCV as indicated in the diagram. Tumor volumes were measured every other day during 2 weeks. Adwt-RGD and ICOVIR5-TK-L+GCV induced a statistically significant delay in tumor progression as compared to saline-treated controls. No significant difference was observed between Adwt-RGD and ICOVIR5TK-L+GCV treatments. Kaplan-Meier survival analysis showed a statistically significant increase in median survival of mice receiving Adwt-RGD and ICOVIR5-TK-L as compared to saline treated controls. (B) Antitumor effect of a single iv dose/mouse of 5×10¹⁰ vp ICOVIR5-TK-L followed by 6 doses of GCV administered as indicated in the diagram. Statistically significant tumor growth delay and increase in median survival was observed in treated animals as compared to controls. Volumes expressed as fold increase from volume at day 0 (V₀). Results expressed as means +/− SEM (n = 5 mice/group). *p<0.05, **p<0.01.