Table 1. Analysis of genotypes for Q223R in case-control studies, according to different allelic modes of action.
| Reference | Co-dominant: OR (95% CI)* | Co-dominant: p-value* | Dominant: OR (95% CI)** | Dominant: Chi2 (p-value)** | Recessive: OR (95% CI)** | Recessive: Chi2 (p-value)** |
| Caucasians | ||||||
| Chagnon 1999 [61] | 0.89 (0.74–1.07) | 0.221 | 0.87 (0.52–1.45) | 0.34 (0.557) | 0.66 (0.36–1.19) | 2.19 (0.139) |
| Yiannakouris 2001 [10] | 1.45 (0.75–2.80) | 0.263 | 0.96 (0.38–2.44) | 0.01 (0.924) | 5.54 (1.13–27.27) | 7.40 (0.007) |
| Mattevi 2002 [31] | 1.62 (1.15–2.26) | 0.005 | 1.60 (0.99–2.59) | 4.05 (0.044) | 2.44 (1.16–5.12) | 6.92 (0.009) |
| Portolés 2006 [62] | 0.84 (0.68–1.04) | 0104 | 0.88 (0.65–1.18) | 0.84 (0.360) | 0.62 (0.38–1.03) | 3.96 (0.047) |
| De Krom 2007 [63] | 1.00 (0.73–1.37) | 0.991 | 0.77 (0.45–1.30) | 1.11 (0.293) | 1.33 (0.76–2.30) | 1.14 (0.285) |
| Mergen 2007 [32] | 1.43 (1.03–1.99) | 0.034 | 1.65 (1.06–2.56) | 5.45 (0.020) | 1.31 (0.60–2.83) | 0.55 (0.457) |
| Bienertova 2008 [64] | 0.88 (0.57–1.36) | 0.564 | 1.06 (0.50–2.23) | 0.03 (0.872) | 0.65 (0.30–1.44) | 1.33 (0.248) |
| Masuo 2008 [16] | 1.87 (1.10–3.16) | 0.021 | 2.10 (0.90–4.90) | 3.55 (0.060) | 2.89 (0.88–9.49) | 4.22 (0.040) |
| Overall | I2 = 69.8% | I2 p = 0.002 | 1.13 (0.87–1.45) | 0.368 | I2 = 66.5% | I2 p = 0.004 |
| Asians | ||||||
| Endo 2000 [65] | 0.89 (0.58–1.37) | 0.604 | 1.27 (0.20–8.25) | 0.10 (0.754) | 0.84 (0.49–1.42) | 0.51 (0.475) |
| Wang 2006 [30] | 1.32 (0.7–2.38) | 0.347 | 1.51 (0.75–3.04) | 1.57 (0.210) | 0.39 (0.01–13.37) | 0.61 (0.433) |
| Overall | 1.02 (0.71–1.47) | 0.924 | 1.48 (0.77–2.85) | 0.244 | 0.82 (0.49–1.38) | 0.459 |
| Mixed populations | ||||||
| Guízar-mendoza 2005 [66] | 0.70 (0.36–1.34) | 0.278 | 0.78 (0.33–1.84) | 0.40 (0.527) | 0.33 (0.04–2.74) | 1.86 (0.173) |
| Duarte 2007 [67] | 1.24 (0.89–1.71) | 0.202 | 1.65 (1.02–2.68) | 4.69 (0.030) | 0.86 (0.45–1.65) | 0.24 (0.628) |
| Overall | 1.00 (0.58–1.72) | 0.991 | 1.24 (0.60–2.54) | 0.564 | 0.79 (0.43–1.48) | 0.465 |
| Overall all populations | I2 = 56.7% | I2 p = 0.006 | 1.15 (0.93–1.43) | 0.185 | I2 = 52.0% | I2 p = 0.018 |
Odds ratios and 95% confidence intervals are given. Statistically significant results are shown in bold. Where the overall measure was significantly heterogeneous, the I2 value and its p-value are given instead of the overall measure.
*Values from generalized linear model, overall results from meta-analysis, random model.
**Values from meta-analysis, random model.